Marijuana Compound Linked to Low Alzheimer's Disease Risk

Marijuana compound is associated with lower Alzheimer's disease risk, a new study shows.

Neuroscientists at the University of South Florida said that extremely low levels of delta-9-tetrahydrocannabinol or THC - the active ingredient found in marijuana - can help reduce the risk of Alzheimer's disease.

According to the researchers, the compound works by reducing the production of amyloid beta, a protein that forms clumps in the brain. Abnormal accumulation of this protein is considered as a first sign of Alzheimer's disease. The team at USF says that even small amounts of THC can enhance mitochondrial function and help maintain a healthy brain.

Scientists said that they used extremely low levels of THC and found that at these concentrations, benefits of the compound were greater than the risks. At high concentration, THC is known to cause memory problems.

"THC is known to be a potent antioxidant with neuroprotective properties, but this is the first report that the compound directly affects Alzheimer's pathology by decreasing amyloid beta levels, inhibiting its aggregation, and enhancing mitochondrial function," said study lead author Chuanhai Cao, PhD and a neuroscientist at the Byrd Alzheimer's Institute and the USF College of Pharmacy.

"Decreased levels of amyloid beta means less aggregation, which may protect against the progression of Alzheimer's disease. Since THC is a natural and relatively safe amyloid inhibitor, THC or its analogs may help us develop an effective treatment in the future," Cao added, according to a news release.

Marijuana is an easily accessible drug. According to recent estimates from the Centers for Disease Control and Prevention, more teens are smoking marijuana than cigarettes. Most teens and young adults believe that marijuana is a safe drug.

The research has shown that marijuana or rather the active ingredient THC can reduce chronic pain. However, using marijuana can lead to other health problems. A recent study by Oxford University researchers had shown that THC can cause short-term paranoia.

The study is published in the Journal of Alzheimer's Disease.